I have been having a recent bout with my wife's computer.
I was hoping that when I upgraded the machine, it would also make the game work faster. The game did load and operate faster and better, however...
She upgrades to Norton AV 2007 and ever since then, it takes up to 10 minutes for Horizons to boot, and portalling was just as bad once in-game.
I tried defragging, moving the game to a different hard drive, reducing the settings on the ATI 1950 Pro card, but still no fun.
So I used a program I use at work that scans files and registry accesses, and what do I find... Norton AV is scanning EVERY file that is being accessed from the game system which slows it down to a crawl.
I am temporarily disabling real time scan but need to figure out if by excluding the Horizons directory, will it exclude it from the real time scan as well.
If you have OMG slow loadups and portalling, you may want to look into disabling your NAV.