I noticed till now a few (minor) things doing the quests.
Jolly 'Ole Nicolas
Destination Kion - Geleon doesn't take the springs
Destination Mahagra - Revaan doesn't recognise the present but just wants to make you a scholar

Hermey the misfit gnome quest
Dialog with Dibriano
last bit
hmm, my notes are victim of spilled water but there is a bit with (race) instead of the actual race.

The required flame wisp essence isn't recognised when brought back to ? (notes are unreadable so ... can't remember all names of NPC's or quests) a real quest-stopper.

one quest greyed out for some reason - after giving the green ore to the jeweller, you have to wait, I got the message that she was ready but the quest was grey and she forgot all about it

so far...
as a new player to blight I don't know if this is what you're looking for.

Oh, and I noticed (is it the new client or??) that some things are not coloured. some flowers in Tazoon, some gnomes at the festival ground.