Devs are aware of an issue that came up today where some ability hotkeys (most commonly Sprint and Emblems) aren't working (they hang in the queue (bottom box)). It's a hit and miss some abilities hang and some don't, like Focus of Spririt, too.
They are working on a fix, so please be patient. It's a sim issue, so the fix won't require a restart nor a new client. It's one of those fixes where things just start working again "automatically", once fixed.